Swine vesicular disease (SVD)
GENERAL INFORMATION :
IN A FEW LINES :
Swine vesicular disease (SVD) is a contagious viral disease of pigs. SVD may be clinically indistinguishable from foot-and-mouth disease (FMD) en vesicular stomatitis (VS). The differential diagnosis with FMD and VS can be done in the laboratory. Strains of swine vesicular disease virus (SVDV) vary in virulence, and the disease may be subclinical, mild or severe. SVD is a pen disease that spread by direct contact between pigs or indirectly by contact with contaminated faeces and by swill feeding. The resistance of the virus to inactivation may lead to recrudescence.
Recently only Italy has reported outbreaks of SVD, but the virus is probably present in other parts of the world too.
Diagnosis of the disease is made initially on clinical grounds and subsequently confirmed in the laboratory by classical virological, serological or molecular biological methods. Preferred samples for virus detection are epithelium, vesicular fluid, serum (or EDTA-blood) and faeces (virus isolation, Ag-ELISA, real-time RT-PCR).
Since any vesicular condition in pigs may be foot-and-mouth disease, special precautions must be taken for the safe packaging of suspected samples and the laboratory diagnosis of clinical cases of all vesicular virus diseases should be done within biosecure facilities BSL3.
Vaccines are not available and therefore stamping-out will be applied.
ROLE OF CODA-CERVA :
CODA-CERVA is the Belgian National Reference Laboratory for swine vesicular disease.
The laboratory has the necessary authorizations and facilities to isolate the virus under safe conditions. The personnel are experienced in serological tests, virus isolation and molecular diagnosis of SVD virus from clinical samples.
TEAM OF SCIENTISTS :
CODA-CERVA PUBLICATIONS :
- Goris N, Vandenbussche F, De Clercq K. (2008). Potential of antiviral therapy and prophylaxis for controlling RNA viral infections of livestock. Antiviral Res., 78(1):170-8.
- Goris N, De Palma A, Toussaint JF, Musch I, Neyts J, De Clercq K. (2007). 2'-C-Methylcytidine as a potent and selective inhibitor of the replication of foot-and-mouth disease virus. Antiviral Res, 73(3):161-168.
- De Clercq K. (1998). Reduction of singleton reactors against swine vesicular disease virus by a combination of virus neutralisation test, monoclonal antibody-based competitive ELISA and isotype specific ELISA. Journal of Virological Methods, 70, 7-18.
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